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3541-3544
Rapid Enantiomeric Quantification of an Antiviral Nucleoside Agent (D,L-FMAU, 2'-Fluoro-5-methyl- ,D,L-arabinofurano- syluracil) by Mass Spectrometry
W. Andy Tao,
Lianming Wu, and
R. Graham Cooks
, Feng Wang,
John A. Begley, and
Bernhard Lampert
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3545-3562
Aziridinyl Quinone Antitumor Agents Based on Indoles and Cyclopent[b]indoles: Structure-Activity Relationships for Cytotoxicity and Antitumor Activity
Edward B. Skibo and
Chengguo Xing
, Robert T. Dorr
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3563-3571
Measuring Molecular Similarity and Diversity: Total Pharmacophore Diversity
Gergely M. Makara
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3572-3581
Toward the Quantitative Prediction of T-Cell Epitopes: CoMFA and CoMSIA Studies of Peptides with Affinity for the Class I MHC Molecule HLA-A*0201
Irini A. Doytchinova and
Darren R. Flower
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3582-3591
 -Amino Acid Phenolic Ester Derivatives: Novel Water-Soluble General Anesthetic Agents Which Allosterically Modulate GABAA Receptors
Alison Anderson,
Delia Belelli,
D. Jonathan Bennett,
Kirsteen I. Buchanan,
Anna Casula,
Andrew Cooke,
Helen Feilden,
David K. Gemmell,
Niall M. Hamilton,
Edward J. Hutchinson,
Jeremy J. Lambert,
Maurice S. Maidment,
Ross McGuire,
Petula McPhail,
Susan Miller,
Annalisa Muntoni,
John A. Peters,
Francis H. Sansbury,
Donald Stevenson, and
Hardy Sundaram
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3592-3598
Ligand-Protein DataBase: Linking Protein-Ligand Complex Structures to Binding Data
Olivier Roche,
Ryuichi Kiyama, and
Charles L. Brooks, III
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3599-3605
Hydrophilic, Pro-Drug Analogues of T138067 Are Efficacious in Controlling Tumor Growth In Vivo and Show a Decreased Ability To Cross the Blood Brain Barrier
Steven M. Rubenstein,
Vijay Baichwal,
Holger Beckmann,
David L. Clark,
Walter Frankmoelle,
Daniel Roche,
Edit Santha,
Susan Schwender,
Martin Thoolen,
Qiuping Ye, and
Juan C. Jaen
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3606-3615
Synthesis and Antitumor Activity of Conjugates of Muramyldipeptide, Normuramyldipeptide, and Desmuramylpeptides with Acridine/Acridone Derivatives
Krystyna Dzierzbicka and
Aleksander M. Ko odziejczyk
, Barbara Wysocka-Skrzela
, Andrzej My liwski and
Danuta Sosnowska
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3616-3621
Inhibition of Cancer Cell Growth by Ruthenium(II) Arene Complexes
Robert E. Morris,
Rhona E. Aird,
Piedad del Socorro Murdoch,
Haimei Chen,
Jeff Cummings,
Nathan D. Hughes,
Simon Parsons,
Andrew Parkin,
Gary Boyd,
Duncan I. Jodrell, and
Peter J. Sadler
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3622-3631
Synthesis of Sulfaphenazole Derivatives and Their Use as Inhibitors and Tools for Comparing the Active Sites of Human Liver Cytochromes P450 of the 2C Subfamily
Nguyêt-Thanh Ha-Duong,
Sylvie Dijols,
Cristina Marques-Soares,
Claire Minoletti,
Patrick M. Dansette, and
Daniel Mansuy
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3632-3644
Amino Acid/Spermine Conjugates: Polyamine Amides as Potent Spermidine Uptake Inhibitors
Mark R. Burns,
C. Lance Carlson,
Scott M. Vanderwerf,
Josh R. Ziemer,
Reitha S. Weeks,
Feng Cai,
Heather K. Webb, and
Gerard F. Graminski
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3645-3652
Design, Synthesis, and Evaluation of a Long-Acting, Potent Analogue of Gonadotropin-Releasing Hormone
Shai Rahimipour,
Nurit Ben-Aroya,
Mati Fridkin, and
Yitzhak Koch
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3653-3664
N-Benzylpolyamines as Vectors of Boron and Fluorine for Cancer Therapy and Imaging: Synthesis and Biological Evaluation
Bénédicte Martin,
Françoise Possémé,
Caroline Le Barbier,
François Carreaux,
Bertrand Carboni,
Nikolaus Seiler,
Jacques-Philippe Moulinoux, and
Jean-Guy Delcros
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3665-3672
Selective, High Affinity Peptide Antagonists of -Melanotropin Action at Human Melanocortin Receptor 4: Their Synthesis and Biological Evaluation in Vitro
Maria A. Bednarek,
Tanya MacNeil,
Rubana N. Kalyani,
Rui Tang,
Lex H. T. Van der Ploeg, and
David H. Weinberg
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3673-3681
Investigation of 5-Nitrofuran Derivatives: Synthesis, Antibacterial Activity, and Quantitative Structure-Activity Relationships
José Ricardo Pires,
Cristina Saito,
Suely L. Gomes,
Astréa M. Giesbrecht, and
Antonia T-do Amaral
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3682-3691
Influence of Polyamine Architecture on the Transport and Topoisomerase II Inhibitory Properties of Polyamine DNA-Intercalator Conjugates
Lu Wang,
Harry L. Price,
Jane Juusola,
Martin Kline, and
Otto Phanstiel IV
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3692-3699
Synthesis and Antitumor Activity of Ester-Modified Analogues of Bengamide B
Frederick R. Kinder, Jr.,
Richard W. Versace,
Kenneth W. Bair,
John M. Bontempo,
David Cesarz,
Steven Chen,
Phillip Crews,
Ania M. Czuchta,
Christopher T. Jagoe,
Yin Mou,
Raphael Nemzek,
Penny E. Phillips,
Long D. Tran,
RunMing Wang,
Susan Weltchek, and
Sonya Zabludoff
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3700-3709
Utility of Azapeptides as Major Histocompatibility Complex Class II Protein Ligands for T-Cell Activation
Michael Hart and
Craig Beeson
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3710-3720
Design, Synthesis, and Biological Evaluation of Novel Nucleoside and Nucleotide Analogues as Agents against DNA Viruses and/or Retroviruses
Gholam Hossein Hakimelahi,
Tai Wei Ly,
Ali A. Moosavi-Movahedi,
Moti L. Jain,
Maryam Zakerinia,
Hady Davari,
Hui-Ching Mei,
Thota Sambaiah,
Ali A. Moshfegh, and
Shahram Hakimelahi
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3721-3729
Physicochemical Determinants of Passive Membrane Permeability: Role of Solute Hydrogen-Bonding Potential and Volume
Jay T. Goodwin,
Robert A. Conradi,
Norman F. H. Ho, and
Philip S. Burton
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3730-3745
Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis
Kevin J. Duffy,
Michael G. Darcy,
Evelyne Delorme,
Susan B. Dillon,
Daniel F. Eppley,
Connie Erickson-Miller,
Leslie Giampa,
Christopher B. Hopson,
Yifang Huang,
Richard M. Keenan,
Peter Lamb,
Lynnette Leong,
Nannan Liu,
Stephen G. Miller,
Alan T. Price,
Jon Rosen,
Rakhi Shah,
Tony N. Shaw,
Heather Smith,
Kenneth C. Stark,
Shin-Shay Tian,
Curtis Tyree,
Kenneth J. Wiggall,
Lily Zhang, and
Juan I. Luengo
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3746-3749
Synthesis of 1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole Analogues as Novel Antiplatelet Agents
Fang-Yu Lee,
Jin-Cherng Lien,
Li-Jiau Huang,
Tsang-Miao Huang,
Sheng-Chung Tsai,
Che-Ming Teng,
Chin-Chung Wu,
Fong-Chi Cheng, and
Sheng-Chu Kuo
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3750-3753
N-Succinyl-(-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin: An Extracellularly Tumor-Activated Prodrug Devoid of Intravenous Acute Toxicity
Anne-Marie Fernandez,
Kim Van derpoorten,
Luc Dasnois,
Karim Lebtahi,
Vincent Dubois,
Thomas J. Lobl,
Sanjeev Gangwar,
Cecilia Oliyai,
Evan R. Lewis,
Dan Shochat, and
André Trouet
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3754-3757
Synthesis and Cytotoxicity on Sensitive and Doxorubicin-Resistant Cell Lines of New Pyrrolo[2,1-c][1,4]benzodiazepines Related to Anthramycin
Nicole Langlois,
Anne Rojas-Rousseau,
Christiane Gaspard,
Georges H. Werner,
Francis Darro, and
Robert Kiss
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ADDITIONS AND CORRECTIONS
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3758-3758
| 2000 Alfred Burger Award Address in Medicinal Chemistry. From Models to Molecules: Opioid Receptor Dimers, Bivalent Ligands, and Selective Opioid Receptor Probes.
Philip S. Portoghese:
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